Instituto Butantan is a Brazilian biologic research center affiliated to the São Paulo State Secretary of Health. Considered one of the major scientific centers in the world, Butantan is the largest immunobiologicals and biopharmaceuticals producer in Latin America (and one of the largest of the world). It is world-renowned for its collection of poisonous snakes, including as well venomous lizards, spiders, insects and scorpions. By extracting the reptiles and insects' poisons, the Institute develops vaccines against many diseases, which include tuberculosis, rabies, tetanus and diphtheria. The center also produces antidotes to the bites of poisonous animals.