Strasbourg (, French pronunciation: ) is the capital and largest city of the Grand Est region of France and is the official seat of the European Parliament. Located close to the border with Germany in the historic region of Alsace, it is the capital of the Bas-Rhin département. In 2014, the city proper had 276,170 inhabitants and both the Eurométropole de Strasbourg (Greater Strasbourg) and the Arrondissement of Strasbourg had 484,157 inhabitants. Strasbourg's metropolitan area had a population of 773,347 in 2013 (not counting the section across the border in Germany), making it the ninth largest metro area in France and home to 13% of the Grand Est region's inhabitants. The transnational Eurodistrict Strasbourg-Ortenau had a population of 915,000 inhabitants in 2014. Strasbourg is the seat of several European institutions, such as the Council of Europe (with its European Court of Human Rights, its European Directorate for the Quality of Medicines and its European Audiovisual Observatory) and the Eurocorps, as well as the European Parliament and the European Ombudsman of the European Union. The city is also the seat of the Central Commission for Navigation on the Rhine and the International Institute of Human Rights. Strasbourg's historic city centre, the Grande Île (Grand Island), was classified a World Heritage site by UNESCO in 1988, the first time such an honour was placed on an entire city centre. Strasbourg is immersed in the Franco-German culture and although violently disputed throughout history, has been a cultural bridge between France and Germany for centuries, especially through the University of Strasbourg, currently the second largest in France, and the coexistence of Catholic and Protestant culture. The largest Islamic place of worship in France, the Strasbourg Grand Mosque, was inaugurated by French Interior Minister Manuel Valls on 27 September 2012. Economically, Strasbourg is an important centre of manufacturing and engineering, as well as a hub of road, rail, and river transportation. The port of Strasbourg is the second largest on the Rhine after Duisburg, Germany.