Matsumoto is a city located in central Nagano Prefecture, in the Chūbu region of Japan. It is a city located in Nagano Prefecture. Matsumoto is designated as a Special City. As of 1 October 2016, the city had an estimated population of 241,102 and a population density of 246 persons per km². Its total area was 978.47 square kilometres (377.79 sq mi).